MAPPING MECHANISTIC PATHWAYS OF ACUTE ORAL SYSTEMIC TOXICITY USING CHEMICAL STRUCTURE AND BIOACTIVITY MEASUREMENTS

Mapping Mechanistic Pathways of Acute Oral Systemic Toxicity Using Chemical Structure and Bioactivity Measurements

Regulatory agencies around the world have committed to reducing or eliminating animal testing for establishing chemical safety.Adverse outcome pathways can facilitate replacement by providing a mechanistic framework for identifying the appropriate non-animal methods and connecting them to apical adverse outcomes.This study separated 11,992 chemical

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Virtual reality intervention to improve apathy in residential aged care: protocol for a multisite non-randomised controlled trial

Introduction Apathy is a prevalent neuropsychiatric symptom for older adults residing in aged care.Left untreated, apathy has been associated with accelerated cognitive decline and increased risk of mortality.Reminiscence therapy is commonly used in aged care and has demonstrated to reduce apathy.Traditional methods of reminiscence use physical obj

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Losing the wait: improving patient cycle time in primary care

Inefficient clinic systems leading to prolonged wait times at primary care clinics are a source of frustration for patients, physicians, staff and administration.Measuring and shortening cycle time has the potential to improve patient experience, staff satisfaction and patient access by moving more patients through in a shorter cycle time.Limited s

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